TGFB1 and Interstitial cardiac fibrosis: Due to the presence of IL-6 receptors in adult cardiac fibroblasts,47 IL-6 applications can promote collagen production, proliferation, and phenotypic conversion to myofibroblasts of cardiac fibroblasts in experimental studies.48,49 Furthermore, in IL-6 knockout diabetic mice, cardiac interstitial fibrosis was alleviated by modulating transforming growth factor beta 1 (TGFβ1) and miR-29 pathways.50 In the current research, Cedrol attenuated cardiac inflammation which was presented by a decrease in the IL-6 concentration in the heart tissue of LPS-Cedrol 15 and LPS-Cedrol 30 groups (Figure 2).