In rats with rheumatoid arthritis, Cedrol administration reduced the secretion of pro-inflammatory cytokines and inflammation-related mediators through inhibition of phosphorylated-JAK3 protein.21 In another rat model of arthritis, treatment with Cedrol revealed a potent anti-inflammatory impact.18 In an in-vitro study, Cedrol significantly reduced inflammatory response in IL-1β-treated chondrocytes through promoting miR-542-5p expression.51 Moreover, Cedrol reduced the inflammatory response in fibroblast-like synoviocytes treated with LPS.52 The gene discussed is JAK3; the disease is rheumatoid arthritis.