TARDBP and amyotrophic lateral sclerosis: The TAR-DNA binding protein 43 (TDP-43) shifts from a reversible dynamic LLPS to an irreversible aggregated state fused in sarcoma (FUS), tau, and α-synuclein, respectively, in aggregates were found in damaged neurons of ALS, FTD, AD, and PD patients, respectively [120,121].