APL, an M3 variant of acute myeloid leukemia (AML), expresses a fusion oncogene (a fusion of PML gene with RARα gene), leading to translation of the PML/RARα chimeric protein, which blocks hematopoietic progenitor cell differentiation and ultimately leads to APL [[26], [27], [28]]. This evidence concerns the gene RARA and acute promyelocytic leukemia.