Ren's study reported that Brucine and Strychnine could increase the expression of DKK1 and APC and decrease the levels of β-catenin, c-Myc, and phosphorylated LRP6 in CRC cells and tumor tissues, which reveals that Brucine and Strychnine induce cell apoptosis and exhibit antitumor activity of CRC probably through suppressing WNT/β-catenin signaling [149]. This evidence concerns the gene DKK1 and neoplasm.