Gai et al. found that Bufalin could inhibit GSK-3β phosphorylation at Ser9 site in HCC cells BEL-7402, and decrease the expression of β-catenin and WNT target gene Cyclin D1 to control the EMT, invasion, and metastasis of HCC cells [129]. This evidence concerns the gene CCND1 and hepatocellular carcinoma.