Huang et al. used magnetic gold nanoparticles for loading with the silencing Bag-1 gene plasmid pGPH1/GFP/Neo-Bag-1-homo-825 and found it to be effective against CRC both in vivo and in vitro, which may be related to the inhibition of WNT/β-catenin signaling pathway [230]. This evidence concerns the gene BAG1 and colorectal carcinoma.