Based on this, the Plasmid-SLERCC@PDA@MUC12 nanoparticles (PSPM-NPs) were constructed to overcome the lncRNA instability using the encoding plasmid and improve the target of SLERCC to RCC cell lines by the incorporation of transmembrane metastasis marker MUC12 antibody. Here, MUC12 is linked to renal cell carcinoma.