Secondly, elevation in progranulin (OR: 1.7069, 95% CI: 1.0654-2.7345, PIVW: 0.0262), TRAIL-R3 (OR: 2.1605, 95% CI: 1.2297-3.7959, PIVW: 0.0074), and IL-6R (OR: 2.4218, 95% CI: 1.0512-5.5795, PIVW: 0.0378) was associated with an increased risk of cerebral aneurysm. The gene discussed is IL6R; the disease is brain aneurysm.