In our study, we identified 20 primary immunodeficiency-related genes associated with three vascular lesions (stroke, cerebral aneurysm, giant cell arteritis), including CD40 association with stroke, IL-6R, and SP-D association with cerebral aneurysm, and Tie-2, MMP-1 association with giant cell arteritis. Here, SFTPD is linked to brain aneurysm.