Firstly, elevated levels of IGFBP-2 (OR: 1.1629, 95% CI: 1.0030-1.3483, PIVW: 0.0455), CEACAM1 (OR: 1.1979, 95% CI: 1.0357-1.3855, PIVW: 0.0150), eotaxin-2 (OR: 1.1119, 95% CI: 1.0251-1.2060, PIVW: 0.0105), and fetuin-A (OR: 1.1960, 95% CI: 1.0001-1.4304, PIVW: 0.0499) were associated with an increased risk of stroke. The gene discussed is AHSG; the disease is Stroke.