Additionally, elevation in four primary immunodeficiency-related genes was associated with an increased risk of postherpetic neuralgia, including Ficolin-3 (OR: 4.0951, 95% CI: 1.2528-13.3857, PIVW: 0.0196), IL-2 receptor α (OR: 2.2062, 95% CI: 1.0027-4.8540, PIVW: 0.0492), THP (OR: 1.9765, 95% CI: 1.0199-3.8607, PIVW: 0.0461), and PON-1 (OR: 3.1751, 95% CI: 1.0147-9.9347,PIVW:0.0471). Here, PON1 is linked to postherpetic neuralgia.