Lastly, an increase in cathepsin D (OR: 1.1303, 95% CI: 1.0152-1.2584, PIVW: 0.0254) and Apo E (OR: 1.0952, 95% CI: 1.0017-1.1974, PIVW: 0.0459) was causally associated with an increased risk of gastrointestinal infections, while an increase in haptoglobin (OR: 0.9435, 95% CI: 0.8991-0.9901, PIVW: 0.0181) was associated with a decreased risk. Here, CTSD is linked to digestive system infectious disorder.