A recent study found that coupling anti-PD-L1 antibody with β-glucan can induce an earlier immune response, infiltration of DCs, and activation of pre-existing T cells in the tumor microenvironment in mice compared to anti-PD-L1 antibody (21).Additionally, our previous research has indicated that combining β-glucan with ICIs and chemotherapy improves median PFS among patients with advanced cancer exhibiting drug resistance and may even reverse drug resistance (22). The gene discussed is CD274; the disease is cancer.