Alzheimer’s disease (AD) is a neurodegenerative condition characterized by the prominent pathological features of extracellular amyloid-beta (Aβ) protein deposition, hyperphosphorylation of Tau protein, and synaptic loss leading to the development of neurofibrillary tangles (NFTs) and eventual neuronal death (127, 128). Here, MAPT is linked to Alzheimer disease.