Lower abundance of Ruminococcaceae g_Faecalibacterium in breast cancer patients [171]. • Ruminococcus torques produced deoxycholic acid induces thermogenesis, alviates obesity [170]. Improved anti-PD-1 efficacy in Rumminococcus enriched obese breast cancer mice [165]. This evidence concerns the gene PDCD1 and obesity due to melanocortin 4 receptor deficiency.