Our result showed that higher purine metabolism in tumor epithelial cells is strongly associated with markers of Treg activation (CCR8, FOXP3, and IL2RA) and levels of ADORA2A, encoding the well-known purine receptor A2AR, in Tregs (Figures 2I, S4C, and S4D; Table S3). This evidence concerns the gene IL2RA and neoplasm.