IL-6 is a pro-inflammatory cytokine involved in various physiological and pathological processes, including immune regulation, inflammation, and cancerogenesis. In CD, the overexpression of IL-6 is associated with the pathogenesis of HHV8-related multicentric CD. IL-6 detection helps identify inflammation-related cells, aiding in distinguishing disease subtypes (2, 20). This evidence concerns the gene IL6 and Cowden disease.