VEGFA and osteosarcoma: reported the construction of a specific aptamer (LC09) of osteosarcoma cells that was conjugated to a PEG-polyethylenimine (PEI) Cholesterol (PPC) lipopolymer, followed by combination with clustered regularly interspaced short palindromic repeats (CRISPR)/CRISPR associated protein 9 (Cas9) plasmids encoding VEGFA (131).