In HCC tissues, the expression of LAG-3 has also increased in the vast majority of tumor-infiltrating lymphocytes with positive PD-1 staining, but it was also found that only a single target of LAG-3 was upregulated in a small number of cases, which suggests that some HCC patients may benefit from the inhibition of the LAG-3 pathway rather than the PD-1 pathway (100). The gene discussed is LAG3; the disease is hepatocellular carcinoma.