Furthermore, treatment of human PD-1xLAG-3 knock-in mice with Regn3767 in combination with cemiplimab (a human anti-PD-1 antibody) demonstrated heightened antitumor effects and facilitated the release of pro-inflammatory factors by tumor-specific T cells, potentially attributed to the disruption of inhibitory signaling mediated by hLAG-3/MHCII in the presence of PD-1/PD-L1 (76, 77). The gene discussed is CD274; the disease is neoplasm.