- In 76% of patients, inflammatory injection site reaction limited to tumor tissue, followed by selective tumor necrosis- Decreased MDSC and transiently increased CD4 Treg cell proportions in blood samples- Transiently increased total NK cells and CD8 T cells in blood- Sustained increase in frequency and absolute count of lymphocytes (mainly CD4 T cells). The gene discussed is CD8A; the disease is neoplasm.