MICU1 and obesity due to melanocortin 4 receptor deficiency: Mitochondrial calcium uptake 1 protein (MICU1) is a regulatory protein in the mitochondrial calcium uniporter complex, which regulates mitochondrial calcium [(Ca2+)m] levels in response to stress from obesity and type 2 diabetes (Shi et al., 2023; Kaye et al., 2024).