Clinical manifestations of MCD are systemic inflammation, flu-like symptoms, night sweats, fever, skin rash, edema, and pleural effusions, along with other common symptoms (hepato-splenomegaly) and laboratory abnormalities (high sedimentation rate, increased C-reactive protein, hypoalbuminemia, thrombocytopenia or thrombocytosis). The gene discussed is CRP; the disease is thrombocytosis disease.