A systematic review focusing on breast cancer found no clear link between opioid use and recurrence rates, underscoring the need for further research [31]. Non-opioid analgesics, including nonsteroidal anti-inflammatory drugs (NSAIDs) and cyclooxygenase 2 (COX-2) inhibitors, are being investigated for their potential benefits in cancer pain management and recurrence prevention. Here, PTGS2 is linked to breast cancer.