SLC5A2 and Cowden syndrome 1: Infliximab and adalimumab hamper the progression of CS. ACE inhibitors, ARBs, aldosterone antagonists, and SGLT-2 inhibitors are the cornerstones of the management of ventricular dysfunction. ICD helps in the prevention of sudden cardiac deaths. Cardiac MRI and FDG-PET scans are essential for monitoring CS progression.