However, adding CogDrisk‐AD risk factors (C‐index from 0.867 to 0.907; C‐index increase, 0.040; 95% CI, −0.007, 0.086) or APOE genotypes (C‐index from 0.867 to 0.867; C‐index increase, 0; 95% CI, −0.054, 0.055) to the model including the AD protein risk score did not significantly improve the predictive performance for new‐onset AD (Table 2). The gene discussed is APOE; the disease is Alzheimer disease.