When the AD risk threshold was set at 0.5% (half of AD incident rate in the study), the AD protein risk score correctly identified 86.8% of AD cases, which was comparable to the CogDrisk‐AD risk factors (86.8%; 10‐year categorical NRI, −0.003; 95% CI, −0.150, 0.080), and higher than APOE genotypes (66.17%; 10‐year categorical NRI, 0.216; 95% CI, 0.073, 0.330). Here, APOE is linked to Alzheimer disease.