At least 23 genes are involved in this pathway, and mutations in any of these genes can affect DNA repair, causing the accumulation of DNA fragmentation, genomic instability, and the occurrence of FA.[3] Among these 23 genes, FANCR is inherited in the AD manner, FANCB is inherited in the XR manner, and the rest are all inherited in the AR manner.[4]FANCA is the most commonly (60%–70%) mutated gene in FA. The gene discussed is FANCA; the disease is Friedreich ataxia.