The diagnosis of POEMS syndrome must meet 2 mandatory criteria, at least 1 major criterion, and at least 1 minor criterion.[8] Here, we report a case exhibiting multiple peripheral neuropathy (mandatory criterion), Castleman disease (major criterion), sclerosing osteopathy (major criterion), elevated serum VEGF (major criterion), enlarged lymph nodes (minor criterion), edema (minor criterion), hypothyroidism (minor criterion), and thrombocytosis (minor criterion). The gene discussed is VEGFA; the disease is Thrombocytosis.