The diagnosis of POEMS syndrome must meet 2 mandatory criteria, at least 1 major criterion, and at least 1 minor criterion.[8] Here, we report a case exhibiting multiple peripheral neuropathy (mandatory criterion), Castleman disease (major criterion), sclerosing osteopathy (major criterion), elevated serum VEGF (major criterion), enlarged lymph nodes (minor criterion), edema (minor criterion), hypothyroidism (minor criterion), and thrombocytosis (minor criterion). Here, VEGFA is linked to Castleman disease.