TMPRSS2 and Obesity: In fact, more previous observational studies suggested the immunosuppressive effect of cancer and cancer-directed therapy increased the susceptibility of cancer patients to life-threatening complications from COVID-19.[5,27] The development and progression of prostate cancer and COVID-19 are significantly influenced by common comorbidities such as hypertension, diabetes mellitus, obesity, old age, as well as molecular factors including androgen receptor signaling and TMPRSS2 expression.