In fact, more previous observational studies suggested the immunosuppressive effect of cancer and cancer-directed therapy increased the susceptibility of cancer patients to life-threatening complications from COVID-19.[5,27] The development and progression of prostate cancer and COVID-19 are significantly influenced by common comorbidities such as hypertension, diabetes mellitus, obesity, old age, as well as molecular factors including androgen receptor signaling and TMPRSS2 expression. The gene discussed is TMPRSS2; the disease is obesity due to melanocortin 4 receptor deficiency.