TP53 and cancer: High expression of NME5 was associated with poor prognosis in breast cancer patients, and it may play a role in inhibiting cancer.[39] Some studies have shown that NME5 plays an anti-cancer role in bladder cancer.[40] NME5 could also be referred to as a p53-induced apoptosis-beta inhibitor (IPIA-beta), which could prevent Bax cell death.[41] In a word, the five genes related to iodine metabolism and THCA subtype in the diagnostic model were closely related to the growth, proliferation, migration, and treatment of cancer.