High expression of NME5 was associated with poor prognosis in breast cancer patients, and it may play a role in inhibiting cancer.[39] Some studies have shown that NME5 plays an anti-cancer role in bladder cancer.[40] NME5 could also be referred to as a p53-induced apoptosis-beta inhibitor (IPIA-beta), which could prevent Bax cell death.[41] In a word, the five genes related to iodine metabolism and THCA subtype in the diagnostic model were closely related to the growth, proliferation, migration, and treatment of cancer. The gene discussed is NME5; the disease is urinary bladder cancer.