PRRT2 and cancer: PRKCQ is a T-cell specific PKC subtype that plays a key regulatory role in nuclear receptor-mediated active suppression.[35] PRKCQ played a role in both PTC and gastrointestinal stromal tumors.[36] PRKCQ could affect multiple processes of cancer, including cell proliferation, migration, and invasion.[37] In colorectal cancer tissues, miR-128-1-5p can inhibit cell proliferation by suppressing PRKCQ expression.[38] NME5 (Non-metastatic 5), as a member of the NME family, could participate in promoting tumor development.