As to key gene ALDH5A1, existing studies have found that ALDH5A1 was regulated by hepatocyte nuclear factor 4 alpha in renal cell carcinoma, and ALDH5A1 was up-regulated in COAD stem cells, except for these, there was little insight into the regulation mechanism of ALDH5A1 in tumors, and there were no studies that revealed the relationship of ALDH5A1 with COAD, or its key role in COAD progression at the molecular level.[45]. Here, HNF4A is linked to hereditary clear cell renal cell carcinoma.