GSDME and neoplasm: GSDME is mainly highly expressed in normal cells and is low in tumor cells due to the hypermethylation of its promoter.[10] Decitabine, a DNA methyltransferase Inhibitor, can inhibit hypermethylation in the GSDME promoter region, promote tumor cell pyroptosis, and enhance the immune effect, thus inhibiting tumor growth.[11] These studies all confirmed the potential of pyroptosis-related genes in the prognostic stratification and as therapeutic targets.