RORC and colon adenocarcinoma: Pan et al revealed that the expression of RORC was reduced in COAD tissues and COAD patients compared with normal tissues using real-time quantitative PCR, and the down-regulation expression of RORC was accompanied by liver metastases.[61] Hu et al[62] proved by cell culture that RORC agonists could enhance Th17 cell differentiation, migration, and infiltration, inhibits TGF and Treg cell differentiation, and increase antitumor effector T cell function.