TGFB1 and neoplasm: TNF-α could kill tumor cells and stimulate neutrophil recruitment.[72] And then under conditions without TGF-β, neutrophils could secret cytokines TNF-α and express T cell receptor (TCR), recruit CD8+ T cells, and enhance antibody-dependent cell-mediated cytotoxicity, ultimately inhibiting tumor growth.[73] We did find out by immune infiltration analysis that neutrophils were infiltrated significantly more in the low-risk group compared with the high-risk group (Fig. 19).