For example, gasdermin E (GSDME)-mediated pyroptosis released high mobility group box 1 protein, which induced tumor cell proliferation through the ERK1/2 pathway, while Granzyme A in cytotoxic lymphocytes cleaved the lysine at positions 244 and 229 of the gasdermin B (GSDMB) protein in tumor cells, activated GSDMB-induced pyroptosis, thus killed tumor cells.[7] As can be seen from the above studies, pyroptosis is a double-edged sword for tumors. The gene discussed is MAPK3; the disease is neoplasm.