There was 1 report suggesting a reduced abortion rate, which was compared with patients with unexplained infertility, but the age of patients with unexplained infertility was significantly higher than that of patients with endometriosis.[3] Other research indicated that there is no significant difference in the abortion rate between spontaneous pregnancy in the same cycle after GnRH-a treatment and the general population.[34] Our study suggested that there was no difference between the early abortion and late abortion GnRH-a group and the HRT group in the rate. The gene discussed is GNRH1; the disease is endometriosis.