TIMP1 and glaucoma: Conley et al discovered that selenium-induced alterations in MMP-2/TIMP-1 secretion may disrupt the balance of extracellular matrix turnover in the traditional outflow channel and produce an increase in intraocular pressure that ultimately results in glaucoma.[32] Elevated selenium levels were found to increase resistance to outflow in cultivated trabecular meshwork cells, according to an analysis of selenium’s effects.[6] These findings showing a larger daily consumption of selenium may be linked to an increased incidence of glaucoma, which coincides with the results of our study.