However, a group of GBM samples presented SCN1A expression level similar to non-tumoral tissue and significantly different from the rest of the GBM sample, and it was mainly identified as the proneural GBM subtypes [45] (Proneural: 7.4 ± 1.1 log2, n = 163; Mesenchymal: 6.2 ± 1.2 log2, n = 166; Classical: 6.1 ± 1.1 log2, n = 199; p = 4.6E-19 Proneuronal vs Classical, Bonferroni correction; p = 3.9E-15 Proneuronal vs Mesenchymal, Bonferroni correction, Fig. 1F). This evidence concerns the gene SCN1A and glioblastoma.