When analyzing all GBM patients with an identified proneural subtype in a pooled setting and selecting the 7.7 log2 value as the cut-off point for SCN1A transcript expression, the 120-month overall survival (OS) rate, as depicted in the Kaplan-Meier survival curves (Fig. 1H), was significantly lower (p = 0.039; log-rank test) ) for those with SCN1A transcript levels higher than 7.7 log2 (red curve) compared to those with expression levels below the cut-off (green curve). This evidence concerns the gene SCN1A and glioblastoma.