The involvement of ferroptosis in the progression of liver fibrosis in nonalcoholic steatohepatitis (NASH) with T2DM has been linked to the insufficiency of AGE receptor 1 (AGER1), an in vivo scavenger and protector of AGEs (Gong et al. 2023; Uribarri et al. 2011).Decreased AGER1 expression in hepatocytes may increase the interaction between AGEs and RAGE, potentially leading to an increased prevalence of RAGE-mediated signals (Dehnad et al. 2020) and thereby promoting the progression of ferroptosis. This evidence concerns the gene DDOST and metabolic dysfunction-associated steatohepatitis.