Focusing on the role of ALDH1A3, we and others, have shown that high ALDH1A3 expression is associated with worse prognosis, promotes tumor progression, invasion, and metastasis, and contributes to chemoresistance in multiple cancers, including melanoma, breast, prostate, glioblastoma and colon cancer [12, 17–30]. This evidence concerns the gene ALDH1A3 and colonic neoplasm.