ADIPOQ and obesity due to melanocortin 4 receptor deficiency: On the other hand, low levels of adiponectin are associated with obesity and Type 2 diabetes, and studies suggest adiponectin may suppress cancer growth by modulating a number of intracellular metabolism and proliferation pathways associated with mitogenesis, including TNF-alpha, AMPK and SREBP-1 signalling [110, 111].