INS and Cachexia: The critical role of extracellular Insulin inhibitors in muscle wasting was demonstrated previously in adult Drosophila cachexia models, in which either rasV12-driven tumorous larval disks transplanted in adult flies, or yorkie-driven adult midgut tumors, induced muscle disorganization and wasting through the secretion of ImpL2 (Figueroa-Clarevega and Bilder, 2015; Kwon et al, 2015).