INS and neoplasm: This model is supported by a recent study proposing that in a Drosophila larval model of tumor-induced cachexia, the atrophic fat body fails to export critical extracellular matrix components such as collagen IV/viking, thus contributing to muscle wasting (Bakopoulos et al, 2023), or by the description in mammals of adipose tissue-derived signaling lipids promoting efficient insulin signaling in skeletal muscles (Cao et al, 2008).