The 22RV1 NSD2-KO+ NSD2-L-FKBP12F36V cells successfully grafted and grew to form tumors in vivo; however, dosing of host animals with an FKBP12 degrader significantly diminished the growth of tumor xenografts (Fig. 3e and Extended Data Fig. 5j). This evidence concerns the gene FKBP1A and neoplasm.