NSD1 and posterior cortical atrophy: NSD1 inactivation also diminished hyperproliferative gene pathways (like E2F and G2M; Extended Data Fig. 7h) and had the strongest reduction in H3K36me2 levels upon a single-gene loss (Fig. 3j and Extended Data Fig. 7g), positioning NSD1 as the predominant H3K36 dimethyltransferase in PCa cells.