Of particular interest, some of these upstream regulators have been associated with cardiometabolic traits (though not TG), such as hypercholesterolemia, T2D, heart failure, and hyperglycemia (SIRT6); obesity (C1QTNF2); and weight gain, cardiomyopathy, liver cirrhosis, and insulin resistance (MGLL). The gene discussed is SIRT6; the disease is obesity due to melanocortin 4 receptor deficiency.