NF2/Merlin inactivation is also associated with schwannoma tumorigenesis16, and Merlin suppression with sgNF2 in human HEI-193 schwannoma cells30 stably expressing CRISPRi machinery also attenuated Wnt signaling compared to sgNTC (Supplementary Fig. 4b, c). This evidence concerns the gene NF2 and schwannoma.