In support of the robustness of Wnt signaling across Merlin-intact meningiomas, re-analysis of RNA sequencing data from meningiomas with SSVs targeting TRAF7 (n = 8), PIK3CA (n = 5), AKT1 (n = 7), or SMO (n = 14) revealed no difference in expression of Wnt target genes across these genetic contexts13 (Supplementary Data 4). The gene discussed is PIK3CA; the disease is meningioma.