Merlin-intact meningiomas can encode somatic short variants (SSVs) targeting TRAF7, PIK3CA, AKT1, KLF4, or the Hedgehog pathway17,18, but some of these variants do not drive meningioma tumorigenesis in mice, and others do not drive meningioma cell proliferation or susceptibility to molecular therapy in vitro19–21. The gene discussed is PIK3CA; the disease is meningioma.