KLF4 and neoplasm: Our finding that Merlin post-translational modification can promote Wnt signaling is unexpected considering the well-described tumor suppressor functions of NF2. CNVs deleting NF2 on chromosome 22q are early events underlying Immune-enriched or Hypermitotic meningioma tumorigenesis7,28, but Merlin-intact meningiomas encode SSVs targeting TRAF7, AKT1, or KLF4 that may be tumor-initiating17,18.