β-catenin suppression using siRNAs (siCTNNB1) inhibited meningioma Wnt signaling (Fig. 2e and Supplementary Fig. 5c), but Merlin was required for maximal Wnt pathway activation in meningioma cells even after β-catenin overexpression (Fig. 2f and Supplementary Fig. 5d). The gene discussed is NF2; the disease is meningioma.