Our data show MerlinS13 phosphorylation status and Wnt signaling modify Merlin-intact meningioma growth, but the way(s) in which this mechanism interacts with (or is influenced by) the myriad missense mutations in TRAF7, AKT1, KLF4, or other potential driver mutations that are enriched in Merlin-intact meningiomas remains to be established. Here, AKT1 is linked to meningioma.