With respect to the putative feed-forward circuit we report, in unstimulated meningioma cells, we found (1) that knockdown of endogenous NF2 negatively regulated Tcf/Lef transcription activity (Fig. 2g, columns 1 vs 3, and Fig. 2h, columns 1 vs 2), (2) that over-expression of exogenous NF2 in cells lacking endogenous NF2 could not rescue Tcf/Lef transcriptional activity (Fig. 2h, columns 2 vs 3) and (3) that over-expression of exogenous NF2 in cells expressing endogenous NF2 had no impact on Tcf/Lef transcriptional activity (Fig. 2g, columns 1 vs 2). This evidence concerns the gene NF2 and meningioma.