PRRT2 and meningioma: In support of this hypothesis, we show (1) suppression of PP1A or PKC isoforms partially regulates MerlinS13 phosphorylation (Fig. 3i, j), (2) epistatic MerlinS13D or Merlin∆NTD rescue partially restores Wnt signaling in meningioma cells (Fig. 3c, e), and (3) the non-canonical Wnt pathway regulators AMOT, AMOTL1, AMOTL2, DSG2, and DLG143–45 can be found in proximity to Merlin alongside β-catenin in meningioma cells (Supplementary Data 2).