To validate these findings, IOMM-Lee human meningioma cells encoding endogenous Merlin23 were transduced with short-hairpin RNAs (shRNAs) suppressing NF2 (shNF2), or non-targeted control shRNAs (shNTC), and grown as xenografts in mice (Supplementary Fig. 2a). The gene discussed is NF2; the disease is meningioma.