Taken together with ADNP promotion of sex-dependent neuronal morphogenesis/plasticity (Bennison et al. 2023), ADNP-mediated regulation of steroid biosynthesis genes (Grigg et al. 2020), sexually dichotomized (Malishkevich et al. 2015), estrous cycle (Furman et al. 2005), and gonadotropin-releasing hormone receptor (Gnrhr)-correlated ADNP expression (Kapitansky et al. 2020) all imply potential sex-dependent association of ADNP with cocaine addiction. This evidence concerns the gene GNRHR and cocaine dependence.