ADNP is a leading autism spectrum disorder (ASD)-linked gene (Helsmoortel et al. 2014) and is further associated with Alzheimer’s disease (Gozes 2024), schizophrenia (Dresner et al. 2011), and stress response (Sragovich et al. 2019a, b) and is protective in fetal alcohol syndrome (Poggi et al. 2003; Pascual and Guerri 2007). This evidence concerns the gene ADNP and early-onset autosomal dominant Alzheimer disease.