ADNP/ADNP2 control of erythropoiesis (Dresner et al. 2012) and ADNP/ADNP2 coregulation (Giladi et al. 2007; Malishkevich et al. 2015) with dysregulation association with aging (Kapitansky and Gozes 2019), as well as brain disorders, such as schizophrenia (Dresner et al. 2011; Merenlender-Wagner et al. 2015) and Alzheimer’s disease (Malishkevich et al. 2016). Here, ADNP2 is linked to early-onset autosomal dominant Alzheimer disease.