SOD1 and amyotrophic lateral sclerosis: Directly innervating α-motor neurons are V0c interneurons.26 These interneurons have large cholinergic inputs onto α-motor neurons, known as C-boutons, through which they modulate neuronal excitability and coordination in a task-dependent manner.26,27 In mutant SOD1 mice, genetic silencing of V0c interneurons appears to both worsen28 and improve29 motor function during the early stage of ALS-like phenotype progression.