To associate these SOD1 related changes with oxidative stress, we assessed spinal cord homogenates for levels of lipid peroxidation as previously reported for SOD1G37R mice.22 In contrast to the ALS model, elevated lipid peroxidation was not evident in the Slc31a1+/− mice (Fig. 5C). Here, SOD1 is linked to amyotrophic lateral sclerosis.