Although the specific role of perivascular TDP‐43 inclusions in AD has not been studied before, it is noteworthy that our findings support the previous epidemiological research indicating a worse prognosis in AD patients with TDP‐43 inclusions [19, 20] and patients with quadruple misfolded proteins (Aβ, tau, alpha‐synuclein, and TDP‐43) [21]. Here, TARDBP is linked to Alzheimer disease.