By staining postmortem hippocampal sections from AD patients and non‐demented controls against TDP‐43 and pTDP‐43 together with the astrocytic markers glial fibrillary acidic protein (GFAP), astrocytic endfeet marker Aquaporin‐4 (AQP4), and markers for BBB alterations (CD146) and leakiness (Immunoglobulin A), we demonstrate a close association between perivascular pTDP‐43 or TDP‐43 inclusions and GFAP or AQP4. The gene discussed is MCAM; the disease is Alzheimer disease.