TNF and periodontal disorder: Previous observations also found that daily RSV supplementation (as a nutritional factor in adjunct with NST) would be beneficial in improving serum levels of IL-6 in patients with periodontal disease.60In addition, another study found that RSV administration suppressed the high levels of IL-6 in the gingival tissue of the mice.63In 2014, Tamaki et al evaluated the effects of RSV supplementation on periodontal disease and detected an improvement in serum levels of IL-6 and TNF-α.64