These features could be essential in treating periodontitis.56RSV may promote osteoblast differentiation to boost bone metabolism further.57, 58However, Chin et al showed that when human gingival fibroblasts were treated with RSV for 1 hour, they showed a significant decrease in mRNA accumulation of SIRT1 and a rise in human gingival fibroblast activity, which has a significant effect on improving the periodontal pocket.59The results showed a significant reduction in PPD in RSV and CHX groups. The gene discussed is SIRT1; the disease is periodontitis.