These signatures were validated in 4 independent MM gene expression datasets: MAQC,30 UAMS,29 HOVON65,32 and APEX31 (Supplementary Table S1), comprising 1388 patients, showing significant correlations of TP53 signature score (TP53SS) and LRP1B signature score (LRP1BSS) with OS (Figure 1B) and PFS/EFS (Supplementary Figure S1A). Here, LRP1B is linked to Miyoshi myopathy.