Studies involving individuals who can control HIV in the absence of ARTs show their HIV-specific CD8+ T cells exhibit enhanced polyfunctionality [1,33] and expression of CXCR5 [34–36], which allows the cells to enter the B-cell follicles to interact with T follicular helper (Tfh) cells within lymphoid tissue, a key reservoir of HIV infection [37]. The gene discussed is CD8A; the disease is HIV infectious disease.