CXCR5 and HIV infectious disease: Studies involving individuals who can control HIV in the absence of ARTs show their HIV-specific CD8+ T cells exhibit enhanced polyfunctionality [1,33] and expression of CXCR5 [34–36], which allows the cells to enter the B-cell follicles to interact with T follicular helper (Tfh) cells within lymphoid tissue, a key reservoir of HIV infection [37].