Transcriptome analysis defined mitochondrial dysfunction and expression of key reactive oxygen species (ROS) transcripts including Mdh2, Xdh, Cyc1, Aldh5a1, Aldh1a7 increased in Ccdc93+/- mice suggest mitochondrial-derived ROS production may mediate the observed hypertensive effects, as ROS has been implicated in the mechanisms of hypertension in other settings [53,54]. Here, CYC1 is linked to hypertensive disorder.