At this stage, little research has been done on the mechanisms by which Lactobacillus improves IBD, based on the establishment of transgenic mice with semiknockout of E-cadherin in the intestine, we have clarified that Lactobacillus gasseri ATCC33323 is targeting E-cadherin to exert a therapeutic effect on colitis in mice. This evidence concerns the gene CDH1 and inflammatory bowel disease.