Numerous studies have shown that the use of Lactobacillus may be an alternative method for treating IBD, as several strains of the Lactobacillus genus have been shown to regulate cytokine activity, improve the integrity of the intestinal barrier, and affect proteins such as ZO-1, occludin, claudin1, β-catenin, and E-cadherin. The gene discussed is CDH1; the disease is inflammatory bowel disease.