CD4 and infection: At the same timepoint, caspase-1 did not impact the development of the adaptive immune response, as no difference was observed in the frequency of CD4+IFN-γ+ T cells, CD8+IFN-γ+ T cells and CD4+IL-4+ T cells in the dLNs and at the site of infection of Casp1-/- and C57BL/6 control mice (S4B and S4C Fig).