When evaluating lead variants from the nonstratified analyses for evidence of escape from XCI with regard to AD risk (Figure 3; eTable 10 in Supplement 1), escape was not apparent for the SLC9A7 and MTM1 lead variants but was apparent for NLGN4X, MID1, ZNF280C, and ARGRG4. The MID1 lead variant furthermore displayed a significant female-biased heterogeneity effect (eTable 10 in Supplement 1). This evidence concerns the gene MTM1 and Alzheimer disease.