PLA2R1 and idiopathic membranous glomerulonephritis: Histologically, NELL1-positive MGN cases exhibited a significantly lower prevalence of GBM lesions, such as spikes and crater formation (vs PLA2R1: p < 0.001, vs Negative: p < 0.001) and a higher percentage of segmental spike distribution (vs PLA2R1: p < 0.001) (Fig. 3a, Table 2).