In summary, we described five extra-abdominal and four intra-abdominal round cell/ epithelioid mesenchymal neoplasms sharing EWSR1/FUS::CREM fusions with frequent expression of aberrant epithelial, neuroendocrine and other markers, but distinct from AFH and not fitting with any currently defined mesenchymal entity. This evidence concerns the gene FUS and mesenchymal cell neoplasm.