We herein describe a unique cohort of soft tissue neoplasms characterized by epithelioid/round cell morphology, unusual immunophenotype, and recurrent EWSR1/FUS::CREM fusions, occurring in extra-abdominal deep soft tissue (n = 2), head and neck (n = 3), and intraabdominal (n = 4) sites. Here, EWSR1 is linked to soft tissue neoplasm.