PLAU and osteosarcoma: Treatment with Rh-uPA protein restored the osteosarcoma cell migration (shMTA2-HOS cells, 167.3% increase; shMTA2-143B cells, 114.5% increase) and invasion (shMTA2-HOS cells, 141.2% increase; shMTA2-143B cells, 122.5% increase) by MTA2 depletion, compared with shMTA2-OS cells (Figure 4).