For the 8 gene loci ESR1 rs2234693, CYP19A1 rs700518, ADAM12 rs3740199, ACE I/D rs4340, VDRrs731236, TGF-β rs1982073, FAS rs1800682, ADAMTS5 rs226794, the cumulative sample sizes were deemed sufficient to conclude that they are not correlated with osteoarthritis. The gene discussed is ADAM12; the disease is osteoarthritis.