Compared with those of normal brain tissues, significantly upregulated TP53, HIF1A, JUN, STAT3, RELA, MYC, NFE2L2, HSPA5 and HMOX1, and downregulated MAPK3 were detected in glioma tissues (all p < 0.01, Figure 6). The gene discussed is MAPK3; the disease is central nervous system cancer.