LDB3 and myotonic dystrophy: Interestingly, several targets affected by Srsf2, such as BIN1 (bridging interactor 1), DMPK(Dystrophin myotonica-protein kinase), FHL1(Four-and-a-half Lim domains protein 1), and LDB3(Lim domain binding 3), have been linked to conditions such as centronuclear myopathy, myotonic dystrophy, various X-linked muscle diseases, and myofibrillar myopathy (Nicot et al., 2007; Pathak et al., 2021; Prokic et al., 2014; Thomas et al., 2018; Figure 8A).