Accumulated evidence suggests that non‐shivering thermogenesis restores energy balance by promoting lipolysis and dissipating energy as heat rather than through ATP synthesis, in both Uncoupling protein 1 (Ucp1)‐dependent and Ucp1‐independent manners.[1, 2, 3, 4, 5] Therefore, brown and beige adipose tissues, collectively termed thermogenic adipose tissues, are increasingly recognized as distinctive targets for the alleviation of metabolic diseases associated with obesity. This evidence concerns the gene UCP1 and obesity due to melanocortin 4 receptor deficiency.