Generally, TEXprog cells express higher levels of T‐bet,[23] TCF1,[50, 51] SLAMF6/Ly108 in mice (surface surrogates of TCF1), and CXCR5.[29, 30, 40, 57] This hierarchal relationship was initially described in mouse models of lymphocytic choriomeningitis virus (LCMV) infection and later confirmed in mouse cancer models and patients with various cancer types.[29, 57, 58, 59, 60, 61, 62, 63, 64, 65] Most studies propose a linear model in which TEXprog cells self‐renew and differentiate into TEXterm cells through an intermediate/transitory state. Here, TCF7 is linked to cancer.