CD69 and neoplasm: TRM cells contribute substantially to the intra‐tumoral CD8+ T cell population (CD103+, ≈70%[57, 71, 72]; CD69+ CD103+, ≈30%[73, 74, 75]), and are enriched with tumor reactivity.[55, 71, 76, 77] Notably, intra‐tumoral TRM cells are not spared from exhaustion.