When interacting with programmed death ligand 1 (PD‐L1), it suppresses multiple processes involved in T cell receptor (TCR) signaling.[1, 2] PD‐L1 can also bind to B7‐1, competing with the costimulatory signal transmitted by CD28.[3] The PD‐1/PD‐L1 axis plays an instrumental role in sustaining immune tolerance under physiological conditions[4, 5] while mediating tumor immune evasion. This evidence concerns the gene CD274 and neoplasm.