CD8A and cancer: Among classical TH cells, type 1 helper T (TH1) cells have received significant research interest in cancer.[112, 140] TH1 cells, characterized by the TF T‐bet, can secrete IFNγ and TNFα, thereby activating other immune cells, such as natural killer (NK) cells and cytotoxic CD8+ T cells.[141] Follicular helper T (TFH) cells play a role in both humoral immunity via stimulating the proliferation and differentiation of B cells and cellular immunity via enhancing the function of CD8+ T cells through IL‐21 secretion.[141] TFH cells are considered memory‐like.