TEXterm cells, which constitute the largest proportion of intra‐tumoral tumor‐reactive T cells, can hardly be reinvigorated.[45, 105, 106, 107, 108] Meanwhile, TTSM cells and TEXprog cells, major responders to PD‐1/PD‐L1 blockade, are strictly[40, 69] and preferentially resident in LNs,[56, 59, 61] respectively. Here, CD274 is linked to neoplasm.