Specifically, DCs in TdLNs emerge as critical mediators of LN‐dependent immune activation.[127, 128] As demonstrated by longitudinal sampling and scRNA‐seq, cDC1s maintain a reservoir of TCF1+ CD8+ T cells within the LNs, and the frequency of cDC1s correlates with the strength of anti‐tumor immune response.[121] Although both macrophages and DCs express high levels of PD‐L1 in LNs, only the depletion of DCs or selective deletion of PD‐L1 in DCs significantly impairs the efficacy of anti‐PD‐L1 treatment.[122, 129]. The gene discussed is TCF7; the disease is neoplasm.